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KMID : 1189420230360040030
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Journal of Korean Oriental Medical Ophthalmology & Otolaryngology & Dermatology
2023 Volume.36 No. 4 p.30 ~ p.50
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Analysis of Potential Active Ingredients and Treatment Mechanism of Atractylodes Lancea(Thunb.) D.C and Magnolia Officinalis Rehder et Wilson for Dermatitis Accompanied by Pruritus Using Network Pharmacology
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Hong Ye-Eun
Seo Gwang-Yeel
Kim Byung-Hyun
Kim Kyu-Seok
Nam Hae-Jeong
Kim Yoon-Bum
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Abstract
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Objectives : To investigate the active compounds and therapeutic mechanisms of Atractylodes Lancea(Thunb.) D.C. and
Magnolia Officinalis Rehder et Wilson in the treatment of dermatitis accompanied by pruritus, as well as their potential to complement or replace standard drugs.
Methods : We conducted the network pharmacological analysis. We selected effective ingredients among the active compounds of research target herbs. Then we explore pathway/terms of the common target proteins among research target herbs, fexofenadine and disease.
Results : We selected 9 active compounds are selected from Atractylodes lancea and identified 231 target proteins. Among them, 74 proteins are associated with inflammatory skin diseases that cause pruritus. These proteins are involved in various pathways including, ‘Nitric-oxide synthase regulator activity’, ‘Hydroperoxy icosatetraenoate dehydratase activity, Aromatase activity’, ‘RNA-directed DNA polymerase activity’, ‘Arachidonic acid metabolism’, ‘Peptide hormone processing’, ‘Chemokine binding’ and ‘Sterol biosynthetic process’. Additionally, coregenes are involved in ‘IL-17 signaling pathway’. Similarly, we selected 2 active compounds from Magnolia officinalis and identified 133 target proteins. Among them, 33 proteins are related to inflammatory skin diseases that cause pruritus. These proteins are primarily involved in ‘Vascular associated smooth muscle cell proliferation’ and ‘Arachidonic acid metabolism’. There is no significant difference between the pathways in which coregenes are involved.
Conclusions : It is expected that Atractylodes Lancea will be able to show direct or indirect anti-pruritus and anti-inflammatory effects on skin inflammation accompanied pruritus through suppressing inflammation and protecting skin barrier. Meanwhile, it is expected that Magnolia Officinalis will only be able to show indirect anti-inflammation effects. Therefore, Atractylodes Lancea and fexofenadine are believed to complement each other, whereas Magnolia Officialinalis is expected to provide supplementary support on skin disease.
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KEYWORD
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Pruritus, Dermatitis, Atractylodes lancea(Thunb.) D.C, Magnolia officinalis rehder et wilson, Network pharmacology
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